Colo-60H Cells

The COLO-60H cell line was derived from a biopsy sample taken from an untreated adenocarcinoma in a male patient. Established in 1998, this cell line is of particular interest in cancer research due to its origin in colorectal cancer, a common and often lethal form of cancer that initiates in the lining of the colon or rectum. Adenocarcinomas themselves are characterized by the glandular origin of the tumor cells, which can provide insights into cellular processes such as secretion and absorption that are hijacked during cancer development.

COLO-60H cells exhibit the HLA-A*0201 allele, making them a valuable model for immunological studies, particularly in the context of tumor immunology. The presence of this specific Human Leukocyte Antigen (HLA) type is crucial for the presentation of antigens to T cells, influencing the immune system’s ability to recognize and destroy cancer cells. This characteristic supports the use of COLO-60H in assessing the efficacy of immunotherapeutic agents and in studying the interactions between tumor cells and the immune system in a histocompatible setting. The relevance of this cell line extends to pharmacological research, where it can be used to evaluate drug responses and explore mechanisms of resistance that are critical in the advancement of personalized medicine for colorectal cancer treatment.