EO771 Cells

EO771 is a murine mammary cancer cell line derived from spontaneous tumors in C57BL/6 mice. This line serves as an important preclinical model for studying breast cancer in an immunocompetent setting, due to its compatibility with syngeneic C57BL/6 mouse models. These models facilitate the exploration of interactions between tumor cells and the immune system, providing insights into tumor growth and metastasis.

EO771 cells are classified as luminal B subtype, characterized by being estrogen receptor alpha (ERα) negative, estrogen receptor beta (ERβ) positive, progesterone receptor positive, and ErbB2 (HER2) positive. This classification aligns with luminal B tumors found in humans, which often have poorer prognoses compared to luminal A types. EO771’s luminal B status makes it relevant for investigating hormonal therapy responses; studies have shown the cell line’s sensitivity to anti-estrogen treatments such as tamoxifen and other selective estrogen receptor modulators.

In addition to its phenotypic traits, EO771 has proven useful for studies on tumor metastasis and immune response modulation. Its metastatic behavior mirrors that of human breast cancer, with frequent dissemination to the lungs and other sites, such as the peritoneum and brain. These attributes make EO771 a valuable model for evaluating the efficacy of novel anticancer treatments and understanding tumor-immune system dynamics.