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Imunoanalýza
Immortalized Adult Mouse Dorsolateral Prostate Cells (INK4 -/- DLP)
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Immortalized Cells |
| Tissue Type |
Prostate |
| Organism |
Mouse (M. musculus) |
| Donor History |
INK4a mouse |
| Growth Properties |
Adherent ,fibroblast-like |
| Growth Conditions | |
| Immortalization Method |
Isolated from p16INK4a and p19ARF Knockout Transgenic Mice |
| Full Information |
https://www.abmgood.com/immortalized-adult-mouse-dorsolateral-prostate-cells-ink4-dlp.html |
The Immortalized Adult Mouse Dorsolateral Prostate Cells (INK4 -/- DLP) were derived from a subline of the INK4a mouse, a transgenic knockout that lacks p16INK4a and p19ARF. Both p16INK4a and p19ARF are specific inhibitors of cyclin-dependent kinases Cdk4 and Cdk6 that regulate cell cycle progression. The cells were isolated from the dorsolateral prostate (DLP), which has simple cuboidal epithelium that is somewhat folded. The luminal secretory cells in the epithelium secrete a homogenous eosinophilic substance into the lumen of the DLP. This cell line is a useful model for studying the prostate stroma-epithelium signalling way, which plays an important role in prostate development and cancer progression.
