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Mutant Connexin50 Stably Expressing HeLa Cell Line (Cx50S259Y)
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Stable (KO/Expressing) Cells |
| Tissue Type |
Cervix |
| Organism |
Human (H. sapiens) |
| Donor History |
Female ,31 ,African American ,Cervial cancer |
| Growth Properties |
Adherent ,epithelial-like |
| Growth Conditions |
PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. MEM α ,No Nucleosides Medium (TM512) + 10% Heat-inactivated FBS + 2 mM L-Glutamine (G275) + 1X Non-Essential Amino Acids (TM068) + 1% Penicillin/Streptomycin Solution (G255) ,37.0°C ,5% CO₂. |
| Immortalization Method | |
| Full Information |
This cell line (Cat. T3424) expresses a mutant form of connexin50 (S259Y) associated with cataract development. It offers a model to explore how this specific mutation affects protein sorting and degradation, particularly through lysosomal pathways, and its impact on lens transparency and eye health. This line is valuable for understanding the genetic underpinnings of cataracts and for the development of targeted treatments.Additional Cell Lines from this panel: Cat. T3423 – Mutant Connexin50 Stably Expressing HeLa Cell Line (Cx50S258F)
