SNU-761 Cells

The SNU-761 cell line is a human hepatocellular carcinoma (HCC) model derived from an adult patient. As part of the Cancer Cell Line Encyclopedia (CCLE) and LIMORE (Liver Cancer Model Repository) initiatives, SNU-761 has been extensively characterized at multiple molecular levels. The cell line has been used to explore the genetic and transcriptomic heterogeneity typical of primary liver cancers, including those associated with hepatitis B virus (HBV) infection, which is prevalent in many East Asian HCC cases. Genomic profiling has revealed that LIMORE models such as SNU-761 often retain the mutational and copy number alteration landscapes of primary tumors, including alterations in key oncogenic drivers like TP53, CTNNB1, and FGF19.

SNU-761 and other liver cancer models in the LIMORE collection have undergone high-throughput drug sensitivity screening across a wide panel of chemotherapeutics and targeted agents. These pharmacogenomic datasets have allowed researchers to identify potential biomarkers predictive of response, such as gene-drug associations and synthetic lethalities relevant to common mutations in liver cancer. Furthermore, comparisons of transcriptomic and epigenetic data—such as DNA methylation and histone modification patterns—have helped classify SNU-761 within liver cancer subtypes and assess its functional attributes, including invasiveness and response to pathway-specific inhibitors. This extensive profiling makes SNU-761 a valuable model for studying HBV-related HCC and evaluating personalized therapeutic strategies.