SNU-C5 Cells

The SNU-C5 cell line is a human gastric carcinoma model established from an adult patient with advanced gastric adenocarcinoma. Derived from a primary tumor specimen, SNU-C5 exhibits epithelial morphology and is part of a broader panel of Korean gastric cancer cell lines developed to represent different histological subtypes and molecular profiles found in East Asian gastric cancers. It provides a valuable model for studying the biology of gastric adenocarcinoma and has been widely used in molecular and pharmacogenomic studies.

Multi-omics profiling, including data from projects like the Cancer Cell Line Encyclopedia (CCLE) and the Genomics of Drug Sensitivity in Cancer (GDSC), has provided a detailed view of SNU-C5’s genetic and pharmacological landscape. The cell line demonstrates common alterations associated with gastric cancer, including mutations in TP53 and alterations in pathways such as PI3K/AKT and RTK signaling. Its inclusion in drug sensitivity screening platforms has allowed researchers to identify associations between genomic features and drug responses, enabling preclinical assessment of targeted therapies. Overall, SNU-C5 serves as a reliable in vitro model for exploring therapeutic vulnerabilities and molecular mechanisms in gastric carcinoma.