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Intolerance u zvířat
Biochemie
Imunoanalýza
TLR2 Stable HEK293 Cell Line
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Stable (KO/Expressing) Cells |
| Tissue Type |
Kidney |
| Organism |
Human (H. sapiens) |
| Donor History |
Embryo |
| Growth Properties |
Adherent ,polygonal |
| Growth Conditions |
PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. Dulbecco's Modified Eagle Medium (DMEM) ,High Glucose (TM500) + 10% FBS + 1% Penicillin/Streptomycin Solution (G255) ,37.0°C ,5% CO₂. |
| Immortalization Method | |
| Full Information |
Toll-like receptors (TLRs) are transmembrane proteins which have significant homology to interleukin-1 receptor family. They function as pattern recognition receptors either as homo- or heterodimer for functional activity. TLR2 or toll-like receptor functions as a heterodimer with TLR1 or TLR6. TLR2 had a role in response to viruses and has an association with herpes encephalitis in mice.TLR2 Stable HEK293 Cell Line stably expresses TLR2, CD14, and NF-kB –driven-luciferase. It is valuable in screening TLR2-mediated inflammation inhibitors, acting as a cell-based screen system. The cells carry a hygromycin resistance gene for selection. This cell line is recommended for studies in TLR2-mediated signaling pathways, and further studies in developing drugs targeting TLR-mediated inflammation through both viral and bacterial infections.
