HK EGFP-Cap-D2 Cells

The HK EGFP-Cap-D2 cell line is an engineered variant of Hela Kyoto cells, specifically designed for advanced research in cellular biology and genetic engineering. This cell line expresses enhanced green fluorescent protein (EGFP) fused to the C-terminus of the D2 dopamine receptor, enabling the visualization of receptor dynamics and distribution in real-time under fluorescence microscopy. This feature is particularly beneficial for studying receptor trafficking, signaling pathways, and the effects of pharmacological agents on D2 receptor behavior.

These cells are used extensively in neurological research to understand better the mechanisms underlying dopamine signaling, which is crucial in many neurological disorders such as Parkinson’s disease, schizophrenia, and depression. The fusion of EGFP to the D2 receptor does not affect the receptor’s normal function or its cellular localization, making HK EGFP-Cap-D2 a valuable tool for physiological and pathological studies. The stable expression of EGFP also allows for longitudinal studies in live cells, providing insights into the dynamic processes of receptor regulation and interaction with other cellular components.