C127I Cells

The C127I cell line is a murine mammary gland epithelial cell line, commonly used in biomedical research for its ability to synthesize and secrete recombinant proteins. These cells originate from the mammary gland of the BALB/c mouse and are particularly noted for their epithelial morphology and responsiveness to hormones and other growth factors. The C127I cell line has been instrumental in the study of gene expression, signal transduction pathways related to cancer development, and the production of viral vectors for gene therapy.

One of the key features of the C127I cell line is its ability to be easily transfected, making it a valuable tool for the production of recombinant proteins and for gene editing studies. It supports the replication of various murine retroviruses, facilitating the production of stable recombinant lines expressing desirable genes. This characteristic has made C127I cells especially useful in the fields of molecular biology and genetics, where they are often employed to explore the effects of gene overexpression or knockdown in a controlled environment.