CCD-18Lu Cells

The CCD-18Lu cell line is derived from normal lung fibroblasts of a human adult. These cells were established from the lung tissue of a male patient and are commonly used as a model for studying the behavior of normal human lung fibroblasts. The CCD-18Lu cell line exhibits typical fibroblast morphology, characterized by spindle-shaped cells that grow adherently in culture and form a monolayer.
Researchers utilize CCD-18Lu cells in various studies related to pulmonary biology, including investigations into lung development, repair, and fibrosis. These cells are instrumental in understanding the mechanisms underlying normal lung function and the response of lung fibroblasts to different environmental stimuli, such as cytokines, growth factors, and extracellular matrix components. Additionally, CCD-18Lu cells are employed in studies examining the effects of various drugs and compounds on lung fibroblast proliferation, differentiation, and collagen production.
In cancer research, CCD-18Lu cells serve as a control or reference cell line to compare with lung cancer cell lines, helping to identify specific molecular and cellular alterations associated with lung cancer progression. By providing insights into the behavior of normal lung fibroblasts, the CCD-18Lu cell line contributes to the development of therapeutic strategies for treating lung diseases, including fibrosis and cancer.