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Biochemie
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CHO-CD206 Cells
| Unit |
3 x 10^6 cells/ml |
|---|---|
| Cell Type |
Stable (KO/Expressing) Cells |
| Tissue Type |
Hamster cell lines ,Reproductive system cancer cell lines ,Transformed cell lines |
| Organism |
Chinese hamster |
| Donor History |
Chinese hamster ovary ,non-neoplastic; genetically engineered for CD206 (MRC1/Mannose receptor) surface expression |
| Growth Properties |
Adherent/suspension |
| Growth Conditions |
Culture medium: For adherent cultures: DMEM:Ham's F12 (1:1) ,w: 3.1 g/L Glucose ,w: 2.5 mM L-Glutamine ,w: 15 mM HEPES ,w: 0.5 mM Sodium pyruvate ,w: 1.2 g/L NaHCO3 (Cytion article number 820400a)For suspension cultures: CHO Growth Medium A (from InSCREENeX; InSCREENeX catalog number INS-ME-1039). Supplements: For adherent cultures: Supplement the medium with 5% FBS. Add Geneticin (G418-Sulfat) to achieve a final concentration of 0.5 mg/mL. Dissociation reagent: For adherent cultures: Trypsin-EDTA. Seeding density: 2 to 5 x 10⁴ cells/cm². Freeze medium: As a cryopreservation medium ,we use complete growth medium (including FBS) + 10% DMSO for adequate post-thaw viability ,or CM-1 (Cytion catalog number 800100) ,which includes optimized osmoprotectants and metabolic stabilizers to enhance recovery and reduce cryo-induced stress. Incubation atmosphere: 37°C ,5% CO2 ,humidified atmosphere. |
| Immortalization Method | |
| Full Information |
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CHO-CD206 cells are recombinant Chinese hamster ovary (CHO) cells engineered to stably express human CD206, also known as macrophage mannose receptor 1 (MRC1). CD206 is a type I transmembrane C-type lectin receptor predominantly expressed on macrophages, dendritic cells, and certain endothelial cell populations. The receptor mediates endocytosis and phagocytosis through recognition of mannose-, fucose-, and N-acetylglucosamine-containing glycoconjugates commonly found on pathogens, glycoproteins, and extracellular matrix components. CD206 is strongly associated with alternatively activated (M2-like) macrophages and plays important roles in antigen uptake, tissue remodeling, immune regulation, and clearance of endogenous glycoproteins.
CHO-CD206 cells are widely used in immunology, infectious disease research, and targeted drug delivery studies for characterization of CD206-directed antibodies, glycan-binding ligands, nanoparticles, and macrophage-targeted therapeutic systems. The stable recombinant expression system enables quantitative analysis of receptor-ligand interactions, mannose-dependent uptake mechanisms, receptor internalization, and endocytic trafficking. These cells are particularly useful for evaluating mannose-functionalized drug carriers, imaging probes, antibody-drug conjugates, and macrophage-targeted immunotherapies. In oncology and inflammation research, CHO-CD206 models also support studies investigating tumor-associated macrophage targeting and modulation of immunosuppressive microenvironments. Common applications include flow cytometry, ligand uptake assays, confocal imaging, and high-throughput screening platforms.
Společnost Cytion vznikla v roce 2004 v německém Heidelbergu s jasným vědeckým posláním: dodávat ověřené lidské a zvířecí buněčné linie bez kontaminace, připravené za přísně kontrolovaných laboratorních podmínek.
Postupně se vypracovala ve spolehlivou buněčnou banku, která slouží akademickým laboratořím, biotechnologickým firmám i farmaceutickým výzkumným týmům po celém světě. Klade přitom důraz na reprodukovatelnost výsledků, přísnou kontrolu kvality a dlouhodobá partnerství.
