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Imunoanalýza
HBL-1 Cells
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Tumor Cells |
| Tissue Type |
Lymph |
| Organism |
Human (H. sapiens) |
| Donor History |
Female ,AIDS-related non-Hodgkin lymphoma |
| Growth Properties |
Suspension ,round |
| Growth Conditions |
PriGrow V (TM015) + 10% FBS + 1X GlutaMAX + 1% Penicillin/Streptomycin Solution (G255) ,37.0°C ,5% CO₂ |
| Immortalization Method |
Tumor Cell Line |
| Full Information |
The HBL-1 cell line is derived from an AIDS-SNCCL patient. After immunophenotypic and molecular genetic analysis, derivation of HBL-1 from the original tumor clones was established. The HBL – 1 cell line presents with surface immunoglobulin and B-cell restricted markers as well as a phenotype consistent with SNCCL. This cell line also has a monoclonal infection of Epstein-Barr virus and displays clonal immunoglobulin gene rearrangement. Genetic lesions pertaining to the activation of the c-myc oncogene as well as inactivation of the p53 tumor suppressor gene is consistent with those found in AIDS-SNCCL. HBL-1 cell line is considered useful as a model to study AIDS-NHL lymphomagenesis.
