HCC1428 Cells

HCC1428 is a human breast cancer cell line classified as luminal B based on global gene expression profiling. It originates from a primary breast tumor and retains key characteristics of luminal-type breast cancers, including expression of estrogen receptor (ER). In comparative transcriptomic analyses across breast cancer cell lines and primary tumors, HCC1428 consistently clustered with luminal B subtype tumors, which are distinguished by higher proliferation indices and a gene expression signature distinct from luminal A tumors.

Functionally, HCC1428 cells exhibit intermediate levels of proliferation and differentiation relative to other breast cancer subtypes. They are estrogen-responsive and maintain a mature luminal phenotype, expressing markers associated with differentiated epithelial lineages of the mammary gland. In preclinical studies, luminal B cell lines like HCC1428 are often employed to evaluate endocrine therapies and resistance mechanisms, given their partial dependence on ER signaling combined with increased proliferative capacity compared to luminal A subtypes.

HCC1428 is also part of the Cancer Cell Line Encyclopedia (CCLE), which provides integrated datasets of genetic, transcriptomic, and pharmacologic profiles. These data indicate that HCC1428 carries gene expression and copy number alterations typical of ER-positive, luminal-type breast cancers. This cell line is therefore a valuable model for studying hormone receptor-positive breast cancer, particularly in the context of luminal B-specific biology and response to targeted therapies.