Hs 611.T Cells

Hs 611.T is a human classical Hodgkin lymphoma (cHL) cell line established from the lymph node of a 48-year-old Caucasian female. The line is derived from the T-cell-rich nodular sclerosis subtype of Hodgkin lymphoma, one of the most common cHL subtypes. Hs 611.T grows in suspension with lymphoblast-like morphology. Hodgkin lymphoma-derived cell lines are relatively rare owing to the scarcity of the malignant Hodgkin Reed-Sternberg (HRS) cells within the tumor mass; Hs 611.T provides a valuable in vitro model of cHL biology.
Hs 611.T is applicable in Hodgkin lymphoma research including studies of HRS cell signaling, NF-κB pathway activity, JAK-STAT pathway regulation, surface antigen expression (including CD30, CD15, CD25), and responses to Hodgkin lymphoma-targeted therapies such as brentuximab vedotin (anti-CD30 ADC). The line is also used in immunological assays evaluating T cell suppression, cytokine secretion, and the tumor microenvironment interactions characteristic of cHL. As a BSL-2-classified cell line, it requires appropriate containment measures.