HT-1080 Cells

HT-1080 cells, derived from the connective tissue of a 35-year-old male patient with Fibrosarcoma in 1972, are widely used for studying the mechanisms of tumor invasiveness and metastasis due to their highly aggressive and invasive nature.
HT-1080 cells have been extensively utilized in studies involving cell migration, invasion assays, and the testing of anti-cancer compounds. In the realm of therapeutic development, HT-1080 cells are employed in the screening of anti-cancer drugs and in the evaluation of their effects on cell viability, apoptosis, and metastatic potential.
HT-1080 cells have also been used in research focusing on the extracellular matrix, angiogenesis, and the role of various genes and proteins in cancer progression. HT-1080 cells produce matrix metalloproteinases (MMPs), enzymes that degrade components of the extracellular matrix and play a critical role in tumor invasion and metastasis. This feature makes the HT-1080 cell line useful for studies investigating the regulation of MMPs and their inhibitors.
In summary, the HT-1080 cell line, with its extensive applications in the study of cancer research, cell adhesion, migration, and invasion models, as well as in the development of therapeutic strategies, continues to be a valuable resource in cancer research.