Human IFNAR1-IFNLR1 CRISPR Knockout A549 Stable Cell Line

Unit

1×10⁶ cells / 1.0 ml

Cell Type

Stable (KO/Expressing) Cells

Tissue Type

Lung

Organism

Human (H. sapiens)

Donor History

Male

White

lung cancer

Growth Properties

Adherent

epithelial-like

Growth Conditions

PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. F-12K Medium (Kaighn's Modification of Ham's F-12 Medium) + 10% Heat-inactivated FBS + 1% Penicillin/Streptomycin Solution (G255)

37.0°C

5% CO₂.

Immortalization Method

Full Information

The Human IFNAR1-IFNLR1 CRISPR Knockout A549 Stable Cell Line is a dual knockout cell line derived from A549 human lung carcinoma cells. This cell line has been genetically engineered using CRISPR/Cas9 technology to knock out both the IFNAR1 and IFNLR1 genes, which encode the interferon-alpha/beta receptor alpha chain and the interferon lambda receptor 1, respectively. The simultaneous knockout of these genes disrupts both type I and type III interferon signaling pathways, making this cell line an exceptional tool for comprehensive studies on interferon responses. Applications include research in immunology, virology, and drug discovery, providing critical insights into immune modulation, antiviral defenses, and the development of novel therapeutic agents targeting interferon pathways.Complete list of cell lines from this panel: Cat. T3517 – Human IFNAR1 CRISPR Knockout A549 Stable Cell LineCat. T3518 – Human IFNLR1 CRISPR Knockout A549 Stable Cell LineCat. T3519 – Human IFNAR1-IFNLR1 CRISPR Knockout A549 Stable Cell Line

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Unit	1×10⁶ cells / 1.0 ml
Cell Type	Stable (KO/Expressing) Cells
Tissue Type	Lung
Organism	Human (H. sapiens)
Donor History	Male , 58 , White , lung cancer
Growth Properties	Adherent , epithelial-like
Growth Conditions	PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. F-12K Medium (Kaighn's Modification of Ham's F-12 Medium) + 10% Heat-inactivated FBS + 1% Penicillin/Streptomycin Solution (G255) , 37.0°C , 5% CO₂.
Immortalization Method
Full Information

Přidat mezi Oblíbené

Katalogové číslo: T3519 Kategorie: Buněčné linie, Stable (KO/Expression) Cell Lines

Popis
O značce

Popis

O značce

Applied Biological Materials (abm) je jedním z našich klíčových dodavatelů pro biotechnologický průmysl. Společnost byla založena v roce 2004 a již více než deset let podporuje vědecké objevy v oblasti přírodních věd a vývoje léčiv. Její sídlo se nachází ve Vancouveru v Kanadě. ABM je pro nás neocenitelným partnerem zejména v  oblasti dodávek buněčných kultur, genových a virových vektorů, produktů pro molekulární biologii a PCR, nástrojů pro technologie CRISPR a RNAi, protilátek i základních reagencií pro molekulárně genetické procesy.

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