Immortalized Human Gingival Fibroblasts – hTERT

Gingival fibroblasts play an important role in oral wound healing and are the major constituents of the gingival connective tissue. These cells are important in testing the “biocompatibility”, or toxicity of new dental materials. In the past, toxicity tests in vitro have been performed with non-human and human malignant cell lines such as L929, CCL163, CCL171 and SaOS2. However, due to the malignancy of the described cell lines, the results may or may not be clinical relevant. The Immortalized Human Gingival Fibroblasts- hTERT have the same morphological cellular response in biocompatibility evaluation to primary human gingival fibroblasts and can thus be used to evaluate toxicity of dental materials.