Genetika člověka
Mikrobiologické aplikace
NGS
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Jednokanálové
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PCR, qPCR, RT
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Biochemie
Imunoanalýza
Immortalized Mouse Calvarial Mesenchymal Progenitor Cells (iCALs)
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Immortalized Cells |
| Tissue Type |
Skeletal Muscle |
| Organism |
Mouse (M. musculus) |
| Donor History |
CD-1 Mouse |
| Growth Properties |
Adherent ,fibroblast-like |
| Growth Conditions | |
| Immortalization Method |
Serial passaging and infection with retrovirus carrying loxP-flanked SV40 large T antigen |
| Full Information |
https://www.abmgood.com/immortalized-mouse-calvarial-mesenchymal-progenitor-cells-icals.html |
The bone morphogenetic proteins (BMPs) produced by calvarial cells are crucial in osteoblastic differentiation and bone regeneration, however the limited lifespan of primary cells diminishes their usefulness in translational research. The Immortalized Mouse Calvarial Mesenchymal Progenitor Cell Line (iCALs) retains the morphology and progenitor cell profile phenotype of primary calvarial cells in addition to preserving BMP-2 –induced osteogenic differentiation. These cells are effective for research examining potential novel small molecule therapeutic agents, cranial reconstruction, alleviation of congenital defects, or the intracellular processes responsible for intramembranous bone formation.
