Genetika člověka
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Biochemie
Imunoanalýza
Immortalized Mouse Cortical Collecting Duct Cell Line (mCCD(cl1))
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Immortalized Cells |
| Tissue Type |
Kidney |
| Organism |
Mouse (M. musculus) |
| Donor History |
Liddle mouse |
| Growth Properties |
Adherent ,polygonal |
| Growth Conditions | |
| Immortalization Method |
Spontaneous immortalization |
| Full Information |
https://www.abmgood.com/immortalized-mouse-cortical-collecting-duct-cell-line-mccd-cl1.html |
In aldosterone-sensitive distal nephron (ASDN), mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) activation regulate ionic and water transports through the epithelial sodium channel (ENaC) and the Na+/ K+ pump. The Immortalized Mouse Cortical Collecting Duct Cell Line is a spontaneously transformed Liddle mouse cell line that expresses significant level of functionally active MR and GR, as well as active 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzyme. In addition, this cell line responses to physiological concentrations (K(1/2)= 0.3 nM) of aldosterone, making it useful for binding equilibrium assays and studies on sodium transport response to various mineralocorticoid and glucocorticoid agonists.
