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Imunoanalýza
Immortalized Mouse Mammary Epithelial Cells (iMMEC)
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Immortalized Cells |
| Tissue Type |
Mammary |
| Organism |
Mouse (M. musculus) |
| Donor History |
Female ,6-8-weeks ,C57B/6 mice |
| Growth Properties |
Adherent ,cuboidal |
| Growth Conditions | |
| Immortalization Method |
Serial passaging and electroporation transfection with linearized DNA of E1A and p53DD |
| Full Information |
https://www.abmgood.com/immortalized-mouse-mammary-epithelial-cells-immec.html |
The Immortalized Mouse Mammary Epithelial Cells (iMMEC) is derived by co-expression of adenovirus E1A and dominant-negative p53 (p53DD). This cell line is unique in that 1) it expresses surface markers, including estrogen-receptor alpha (ERα) and retains the functional properties characteristic to mammary epithelial cell and 2) upon lactogenic stimulation it forms dome-like structures indicative of mammary alveoli and secrets β-catenin into the acinar lumen. This cell line is suitable for studies in hormone regulation and 3D dimensional ductal morphogenesis.
