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Immortalized Mouse Mutant Epidermal Keratinocytes (CDC25A 8b)
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Immortalized Cells |
| Tissue Type |
Skin |
| Organism |
Mouse (M. musculus) |
| Donor History |
C57/BL6 Cdc25afl/fl/Cre+ mouse |
| Growth Properties |
Adherent ,cobble-stone |
| Growth Conditions | |
| Immortalization Method |
Spontaneous immortalization |
| Full Information |
https://www.abmgood.com/immortalized-mouse-mutant-epidermal-keratinocytes-cdc25a-8b-cells.html |
Cell division cycle 25 (CDC25) family of phosphatases consists of CDC25A, CDC25B and CDC25C in which regulates the cell cycle progression, and thus are important for the activation of cell cycle checkpoints in response to DNA damage. CDC25A degradation has been associated with cell cycle arrest. Immortalized Mouse Mutant Epidermal Keratinocytes (CDC25A 8b) Cells were isolated from the Cdc25afl/fl/Cre+ mice in which the CDC25A gene is flanked with loxP inserted at exons 1-3 with the Krt14 promoter-driven Cre recombinase (Cre+) in which the expression of CDC25A is absent. abm also provides the Immortalized Mouse Epidermal Keratinocytes (CDC25A F7) Cells (Cat. No. T0299).
