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Immortalized Mouse TMJ Disc Chondrocyte-Like Cells
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Immortalized Cells |
| Tissue Type |
Cartilage |
| Organism |
Mouse (M. musculus) |
| Donor History |
12-week-old female mouse |
| Growth Properties |
Adherent ,fibroblast |
| Growth Conditions | |
| Immortalization Method |
Stable transfection with the vector pGNR145 expressing hTERT |
| Full Information |
https://www.abmgood.com/immortalized-mouse-tmj-disc-chondrocyte-like-cells.html |
The temporomandibular joint (TMJ) is the jaw joint that hinges to allows complex movements related to eating and swallowing. TMJ disc tissue permits mandibular movement and its degeneration has been linked to many clinical pathologies related to joint function, including crepitus, arthritis and headaches. TMJ disc tissue comprises of a complex matrix of cells with regional difference in morphology, including chondrocyte -like cells and fibroblast-like cells. This organization of cells allow for the dissipation of forces acting on the jaw joint. The immortalized Mouse TMJ Disc cell line was derived from chondrocyte-like cells from a 12-week-old female mouse. These cells are designed to be suitable for cell-type specific studies on the physiology and progression of TMJ disc disorders.</span></p>Characterization was conducted by Western blot, qRTPCR, and immunofluorescence
