LC-540 Cells

The LC-540 cell line is an adherent cell model derived from an adult male Fischer rat. Known for its robust growth properties, this cell line has a modal chromosome number of 42, with a karyotypic range of 40 to 43. Approximately 21% of the cells exhibit aneuploidy, although no other structural abnormalities have been reported, indicating a relatively stable genomic profile.

LC-540 cells are tumorigenic, with the ability to form tumors when introduced into rats. This feature makes them particularly valuable for studying oncogenesis and tumor biology in a controlled in vitro environment. Additionally, these cells are susceptible to several viruses, including Herpes simplex virus, Vaccinia virus, Vesicular stomatitis virus, and Human poliovirus 1. This susceptibility renders LC-540 a useful model for virological research, particularly in exploring virus-host interactions, viral pathogenesis, and the development of antiviral strategies.

Due to their specific characteristics, LC-540 cells are instrumental in a range of research applications, including cancer research and virology, where they provide insights into the mechanisms of tumor formation and viral infections.