MuCaP379.1 Cells

MuCaP379.1 is an epithelial prostate cancer cell line also derived from the same primary Pten KO tumor as MuCaP379AP. It forms syngeneic tumors very slowly, often requiring extended periods for tumor detection in immunocompetent mice. This cell line resembles the histological heterogeneity of the original tumor and predominantly exhibits an adenocarcinoma phenotype with high CK8 expression. MuCaP379.1 shows high levels of CD3+ T-cell and CD8+ effector T-cell infiltration, along with an immune gene profile marked by expressions of IFNγ and PD1, correlating with less aggressive tumor behavior. MuCaP379.1 cell line proliferation is barely detectable and has an adenocarcinoma growth pattern with subcutaneous injection. This cell line is particularly useful for examining the immune landscape of prostate tumors and testing immune-based therapeutic approaches in a genetically defined model system.Additional cell lines from the MuCaP model: Cat. T8301 – MuCaP321 CellsCat. T8302 – MuCaP376 CellsCat. T8303 – MuCaP379AP Cells