Nav2.1/β1/Contactin Stable Chinese Hamster Lung Cell Line

Voltage-sensitive sodium channels are the membrane proteins responsible for initiation of the action potentials in most excitable cells. These ion channels are heteromultimeric structures that include the pore-forming α subunit in association with axillary β subunits. In the Na+ channel signaling complex, the glycosyl-phosphatidylinositol (GPI)-anchored protein, contactin (also known as F3, F11), has been shown to play an important role in the regulation of surface density of these channels. The Nav2.1/ β1/Contactin Stable Chinese Hamster Lung (CHL) Cell Line stably expresses rat Nav2.1 and β1 sodium channel subunits and mouse contactin. This cell line has been shown to express increased Na+ channel density in the surface membrane and serves as a useful model in studies relating to neuronal Na+ channel assembly and distributions.