SNU-620 Cells

SNU-620 cells are a human gastric carcinoma cell line established from malignant ascites of an adult patient with poorly differentiated adenocarcinoma. They are part of a panel of gastric cancer cell lines developed to represent diverse histopathological and biological characteristics of gastric tumors. In vitro, SNU-620 cells exhibit a scattered growth pattern with heterogeneous cell distribution and limited attachment to culture substrates, reflecting their origin from a poorly differentiated tumor with minimal desmoplasia. Morphologically, the cells display predominantly round-to-oval contours with a relatively low nuclear-to-cytoplasmic ratio and poorly developed microvilli, as observed through ultrastructural analysis.

SNU-620 cells contribute to the study of gastric cancer biology through their expression of tumor-associated antigens and molecular alterations characteristic of gastric malignancies. Broader characterization of related SNU gastric cancer lines revealed frequent mutations in key oncogenes and tumor suppressors, including p53, highlighting their relevance for investigating genetic instability and oncogenic signaling pathways in gastric carcinoma. These features make SNU-620 cells a useful in vitro model for studies on tumor progression, metastasis, and therapeutic response in gastric cancer.