STC-1 Cells

The STC-1 cell line is a widely used model derived from a murine enteroendocrine tumor. These cells are notable for their robust secretion of various gastrointestinal hormones, including cholecystokinin (CCK), secretin, and somatostatin. Due to their hormone-secreting capabilities, STC-1 cells are instrumental in studying gastrointestinal physiology and the regulation of digestive processes. Their response to nutrient stimulation makes them particularly useful for investigating the mechanisms underlying hormone release and action in the gut.
STC-1 cells exhibit characteristics typical of enteroendocrine cells, including the presence of dense core secretory granules and the ability to form polarized monolayers in culture. These features allow researchers to use STC-1 cells for in vitro models of gut hormone secretion and to explore the interactions between enteroendocrine cells and other cell types in the intestinal epithelium. Additionally, their murine origin provides a relevant model for comparative studies between human and rodent gastrointestinal physiology.