SU-DHL-4 Cells
| Unit |
5 x 10^6 cells/ml |
|---|---|
| Cell Type |
Tumor Cells |
| Tissue Type |
Lymphoma cell lines |
| Organism |
Human |
| Donor History |
Diffuse large B-cell lymphoma |
| Growth Properties |
Suspension |
| Growth Conditions |
Culture medium: RPMI 1640 ,w: 2.0 mM stable Glutamine ,w: 2.0 g/L NaHCO3 (Cytion article number 820700a). Supplements: Supplement the medium with 10% FBS. Freeze medium: As a cryopreservation medium ,we use complete growth medium (including FBS) + 10% DMSO for adequate post-thaw viability ,or CM-1 (Cytion catalog number 800100) ,which includes optimized osmoprotectants and metabolic stabilizers to enhance recovery and reduce cryo-induced stress. Incubation atmosphere: 37°C ,5% CO2 ,humidified atmosphere. |
| Immortalization Method | |
| Full Information |
The SU-DHL-4 cell line is derived from a lymphoblast-like cell isolated from the peritoneal effusion of a 38-year-old Caucasian male patient. This cell line represents a model of diffuse large B-cell lymphoma (DLBCL), one of the most common types of non-Hodgkin lymphoma in adults. The establishment of this cell line has provided valuable insights into the biology of DLBCL, especially concerning the cellular and molecular mechanisms underlying lymphomagenesis and tumor progression.
In research, SU-DHL-4 cells have been extensively utilized to study the efficacy and mechanism of action of various chemotherapeutic and targeted therapeutic agents, reflecting their importance in lymphoma treatment research. The cells express several key immunophenotypic markers associated with B-cell lineage such as CD19 and CD20, which are crucial for the development and function of B-lymphocytes. These markers also make SU-DHL-4 an excellent target for testing B-cell-specific therapies, including monoclonal antibodies and small molecule inhibitors that disrupt critical signaling pathways involved in lymphoma cell survival and proliferation.
Společnost Cytion vznikla v roce 2004 v německém Heidelbergu s jasným vědeckým posláním: dodávat ověřené lidské a zvířecí buněčné linie bez kontaminace, připravené za přísně kontrolovaných laboratorních podmínek.
Postupně se vypracovala ve spolehlivou buněčnou banku, která slouží akademickým laboratořím, biotechnologickým firmám i farmaceutickým výzkumným týmům po celém světě. Klade přitom důraz na reprodukovatelnost výsledků, přísnou kontrolu kvality a dlouhodobá partnerství.
Mikrobiologické aplikace
NGS
Rapid testy
PCR plasty
Třepačky
Suché lázně
Fluorometry
Buněčné kultury
PCR, qPCR, RT
Detekce Mycoplasmat
Reverzní transkripce
Alergie
Intolerance
Elisa
Imunologické analyzátory
Veterinární imunologie
Alergie u zvířat
Intolerance u zvířat
Čtečky identifikačních čipů
Termočipy
Biochemie
Imunoanalýza

