SW-1573 Cells

SW-1573 is a human non-small cell lung carcinoma (NSCLC) cell line derived from the lung tissue of a female patient diagnosed with squamous cell carcinoma. This cell line has been extensively characterized for its genetic, biochemical, and pharmacological properties, making it a valuable model for studying lung cancer biology and drug responses. SW-1573 is known for its epithelial morphology and moderate growth rate in vitro. It has been included in numerous studies to assess the impact of chemotherapeutic agents and targeted therapies in lung cancer.

Genomic analyses of SW-1573 have revealed key mutations relevant to NSCLC pathogenesis. Studies have shown that SW-1573 lacks common driver mutations in KRAS and EGFR, which distinguishes it from other NSCLC cell lines that are frequently used in lung cancer research. Instead, it carries other genomic alterations that contribute to tumor progression and drug resistance. Large-scale pharmacogenomic efforts, such as those in the Cancer Cell Line Encyclopedia (CCLE), have assessed its drug sensitivity profile, identifying vulnerabilities to specific cytotoxic agents and small-molecule inhibitors.

SW-1573 has been employed in radiation biology studies, as it has demonstrated varying sensitivity to ionizing radiation. Researchers have used this cell line to investigate DNA damage response mechanisms and the role of cell cycle checkpoints in lung cancer therapy. Furthermore, enzyme polymorphism studies have confirmed its genetic stability and distinct identity among other tumor-derived cell lines, ensuring its reliability as a research tool.