SW626 Cells

SW626 is a human ovarian cancer cell line established from an adult patient with serous cystadenocarcinoma of the ovary. It has been widely utilized as a model for epithelial ovarian cancer (EOC), particularly for studying tumor biology, drug response, and molecular heterogeneity in high-grade serous carcinoma. Histologically, the SW626 cell line retains characteristics consistent with its serous adenocarcinoma origin and exhibits tumorigenic potential when xenografted into immunocompromised mice, producing solid tumors that recapitulate features of the primary neoplasm.

Genomic profiling of SW626 reveals common alterations frequently observed in ovarian cancers, including disruptions in key regulatory pathways such as TP53 and PI3K/AKT. Molecular analyses have shown that SW626 carries chromosomal aberrations and gene expression patterns representative of high-grade serous ovarian cancer, making it a relevant model for investigating oncogenic signaling, therapeutic vulnerabilities, and resistance mechanisms. The cell line has been included in large-scale cancer genomics projects, where it contributes to drug screening platforms and comparative studies with other ovarian cancer models, helping to define molecular subtypes and inform precision oncology approaches.