T47D Cells

The T47D cell line, originating from the pleural effusion of an infiltrating ductal carcinoma of the breast, has become a critical resource in breast cancer research. T-47D cells are unique in the realm of cancer research for their hormonal expression profile, particularly for carrying receptors for 17 beta estradiol, various other steroids, and calcitonin. Additionally, T47D cells express the WNT7B oncogene.
T47D cells are notable for their progesterone receptor expression not being regulated by estradiol, despite the hormone’s abundance within the cells, setting them apart from MCF7 cells, which are widely recognized for their estrogen receptor positivity and are frequently used to explore estrogen’s role in tumor proliferation and response to therapies.
The utility of the T47D cell line extends to the formation of xenografts in immunodeficient mice, which are valuable for drug testing, observing receptor status changes, and studying angiogenesis.
Furthermore, the T-47D cell line is a resource for cancer gene studies, providing insights into the genomic and proteomic landscape that drives breast cancer. By facilitating a deeper understanding of the proteomic and transcriptomic profiles of breast cancer, the t47d breast cancer cell line aids in the identification of new breast cancer cell phenotypes and the development of targeted therapies.
T47D cells have been instrumental in studying the effects of hormones like progesterone on breast cancer, offering insights into transcriptional regulation, drug resistance, and the development of xenograft models for therapeutic testing.