SHP-77 Cells

The SHP-77 cell line is a human small-cell lung carcinoma (SCLC) model. It was derived from a primary lung tumor and is used extensively in cancer research, particularly for studies focused on lung cancer biology and drug development. SHP-77 cells exhibit the classic characteristics of SCLC, including rapid growth and high tumorigenic potential in xenograft models. This cell line is known for its ability to proliferate in serum-supplemented culture media and has been utilized in various experimental setups, such as studies of oncogenic signaling pathways and therapeutic response to chemotherapeutic agents.

SHP-77 cells are part of the Cancer Cell Line Encyclopedia (CCLE), a resource that enables researchers to correlate genetic profiles with drug sensitivities. Genomic profiling of SHP-77 has revealed mutations and alterations in critical oncogenes and tumor suppressors, providing a platform for studying the molecular mechanisms underlying SCLC pathogenesis. The cell line has also been included in drug screening studies, offering insights into its pharmacological vulnerabilities and aiding in the identification of compounds with therapeutic potential for lung cancer.