ARE‐luc‐CMVH Stably Expressing RAW264.7 Cell Line

Unit

1×10⁶ cells / 1.0 ml

Cell Type

Stable (KO/Expressing) Cells

Tissue Type

Ascites

Organism

Mouse (M. musculus)

Donor History

Male

Balb/c

Adult

Abelson murine leukemia virus-induced tumor

Growth Properties

Adherent

dendritic-like

Growth Conditions

PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. MEM α

No Nucleosides Medium (TM512) + 10% FBS + 2 mM L-Glutamine (G275) + 1% Penicillin/Streptomycin Solution (G255)

37.0°C

5% CO₂.

Immortalization Method

Full Information

The RAW-ARE-luc-CMVH Stable RAW264.7 Cell Line is specifically designed for the study of the antioxidant response element (ARE) pathway, a crucial mechanism in cellular defense against oxidative stress. This cell line, based on the RAW264.7 murine macrophage lineage, stably incorporates a luciferase reporter gene under the control of an ARE-responsive promoter, enhanced by a cytomegalovirus (CMV) enhancer. This setup enables precise, real-time tracking of ARE activation in response to oxidative stressors and toxicological compounds. It is particularly useful in pharmacological research, allowing for the screening and evaluation of drugs that modulate oxidative stress responses, potentially offering therapeutic strategies for diseases characterized by oxidative damage, such as neurodegenerative disorders and cancer. The cell line ensures consistent performance with its stable reporter gene integration, facilitating reliable and reproducible results in studies of oxidative stress and cellular defense mechanisms.Complete list of cell lines from this panel:Cat. T6529 – NFAT‐luc‐CMVH Stably Expressing RAW264.7 Cell LineCat. T6530 – AP‐1‐luc‐CMVH Stably Expressing RAW264.7 Cell LineCat. T6531 – ARE‐luc‐CMVH Stably Expressing RAW264.7 Cell Line

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Unit	1×10⁶ cells / 1.0 ml
Cell Type	Stable (KO/Expressing) Cells
Tissue Type	Ascites
Organism	Mouse (M. musculus)
Donor History	Male , Balb/c , Adult , Abelson murine leukemia virus-induced tumor
Growth Properties	Adherent , dendritic-like
Growth Conditions	PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. MEM α , No Nucleosides Medium (TM512) + 10% FBS + 2 mM L-Glutamine (G275) + 1% Penicillin/Streptomycin Solution (G255) , 37.0°C , 5% CO₂.
Immortalization Method
Full Information

Přidat mezi Oblíbené

Katalogové číslo: T6531 Kategorie: Buněčné linie, Stable (KO/Expression) Cell Lines

Popis
O značce

Popis

O značce

Applied Biological Materials (abm) je jedním z našich klíčových dodavatelů pro biotechnologický průmysl. Společnost byla založena v roce 2004 a již více než deset let podporuje vědecké objevy v oblasti přírodních věd a vývoje léčiv. Její sídlo se nachází ve Vancouveru v Kanadě. ABM je pro nás neocenitelným partnerem zejména v  oblasti dodávek buněčných kultur, genových a virových vektorů, produktů pro molekulární biologii a PCR, nástrojů pro technologie CRISPR a RNAi, protilátek i základních reagencií pro molekulárně genetické procesy.

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