ASB-XIV Cells

ASB-xIV cells, originating from a female Balb/c mouse, closely mimic large cell carcinoma that has been induced by chrysotile asbestos in mouse lung cells. These cells are monolayer adherent with an epithelial morphology, positioning them as an exemplary model for primary squamous cell carcinoma (PSCC) research. Their structural and functional characteristics make them particularly suitable for detailed studies on the cellular processes and pathological mechanisms underlying PSCC.

The ASB-xIV cell line is characterized as an “inflamed” or “hot” tumor, indicating a high degree of immune cell infiltration which makes it more responsive to immunotherapy. This sensitivity is pivotal in using ASB-xIV cells to evaluate the efficacy of immune checkpoint therapies (ICT). These cells have shown significant responsiveness to such treatments, making them invaluable in oncological research focused on immunotherapeutic efficacy. Additionally, while retinoids have been effective in curbing the growth of these cells in transplanted carcinomas in mice, vitamin C has failed to produce a similar effect. Despite their slow doubling time of approximately 70 hours, ASB-xIV cells maintain robust and stable growth, which is crucial for establishing consistent and reliable in vitro cultures necessary for experimental reproducibility.