AT-1 Cells

The AT-1 cell line is a subclone of the parental R3327 rat prostate adenocarcinoma cell line. This particular cell line was derived from the Dunning model, which is a well-established model used to study prostate cancer. The AT-1 subclone is characterized by its relatively slow growth rate and low metastatic potential compared to other subclones derived from the same tumor, such as the MatLyLu (high metastatic potential) and AT-2 (moderate metastatic potential) cell lines. This makes the AT-1 cell line particularly useful for studies focused on the biology of non-metastatic or minimally invasive tumors.

In research settings, the AT-1 cell line has been utilized extensively to investigate the mechanisms of prostate cancer progression and to assess the efficacy of therapeutic agents. The cells generally exhibit a cuboidal morphology and are adherent. They have been shown to respond to hormonal manipulations, which mimics the hormonal responses seen in clinical prostate cancer. Studies using the AT-1 cell line have contributed to a better understanding of the interactions between tumor cells and the microenvironment, angiogenesis, and the molecular pathways involved in cancer progression. Importantly, the AT-1 cell line has been a valuable tool in the development of therapeutic strategies that are less focused on metastasis and more on primary tumor growth and local invasion.