DLD-1 Cells

DLD-1 is a human colorectal adenocarcinoma cell line derived from the distal colon of an adult patient. These cells are epithelial in morphology and were initially established to study colorectal cancer mechanisms and pathology. DLD-1 cells are commonly used in oncology research, particularly in studies focusing on the molecular biology of cancer, gene expression, and the effects of various chemotherapeutic agents.

This cell line is known for its heterozygous KRAS mutation at codon 13, which is a common feature in colorectal cancers, implicating it in cancer cell survival and proliferation. Additionally, DLD-1 exhibits mutations in the APC gene, contributing to the deregulation of the Wnt signaling pathway, a critical element in colorectal carcinogenesis. The robust use of DLD-1 in research provides valuable insights into tumor behavior, drug response, and cancer genetics, making it a vital model in colorectal cancer research and therapeutic development.