Genetika člověka
Mikrobiologické aplikace
NGS
Rapid testy
PCR plasty
Pipetovací špičky
Plasty pro buněčnou kultivaci
Systém pro dlouhodobé skladování vzorků
Zkumavky
Třepačky
Suché lázně
Centrifugy
End Point cyclery
Real-time PCR cyclery
Fluorometry
Spektrofotometry
Izolátory nukleových kyselin
Pipetovací roboty
Biobanking
Live Cell Imaging
Jednokanálové
Multikanálové
Sérologické pipety
Jednorázové pipety
Buněčné kultury
PCR, qPCR, RT
Detekce Mycoplasmat
Reverzní transkripce
Alergie
Intolerance
Elisa
Imunologické analyzátory
Veterinární imunologie
Alergie u zvířat
Intolerance u zvířat
Biochemie
Imunoanalýza
EMCLL-06 Cells
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Tumor Cells |
| Tissue Type |
Blood |
| Organism |
Mouse (M. musculus) |
| Donor History |
IgH.T/IgHTEµ mouse ,B-cell chronic lymphocytic leukemia |
| Growth Properties |
Suspension ,round |
| Growth Conditions |
PriGrow II (TM002) + 10% FBS + 50 μM B-mercaptoethanol + 55 µg/ml Gentamycin (G056) + 1% Glutamax + 1% Penicillin/Streptomycin Solution (G255) ,37.0°C ,5% CO₂ |
| Immortalization Method |
Tumor Cell Line |
| Full Information |
The EMCLL-06 Cells were derived from IgH.T/IgHTEµ mouse models with sporadic SV40 large T antigen expression in mature B cells. The EMCLL-06 Cells provide an animal model for B-cell Chronic Lymphocytic Leukemia (B-CLL). These murine leukemic cells display similar characteristics also found in human B-CLL, in particular in the subgroup of patients with germline IgH V regions associated with poor prognosis. The EMCLL-06 Cells also express a restricted B-cell receptor (BCR) repertoire with several cases of nearly identical CDR3s. These cells are ideal for studies focusing on B-cell Chronic Lymphocytic Leukemia and the identification of genes that are associated with treatment resistance and poor prognosis.
