H-4-II-E Cells

The H-4-II-E cell line is a hepatoma-derived cell line, specifically developed from the liver tissue of an adult rat. This cell line is frequently utilized in research focused on liver physiology and pathology, particularly in studies related to hepatocellular carcinoma and liver metabolism. The H-4-II-E cells are epithelial-like in morphology and are known for their rapid growth rate and high cell density capabilities, making them a valuable model for high-throughput screening and toxicology studies.

Notably, H-4-II-E cells exhibit several differentiated functions of hepatocytes, including albumin secretion, ammonia production, and the presence of cytochrome P450 enzymes. This makes them an excellent tool for studying drug metabolism, enzyme induction, and interactions that may occur in human liver disease. Moreover, these cells have been used to investigate mechanisms of liver regeneration and cancer progression, providing insights into cellular responses to various stimuli such as cytokines and growth factors.