Human IFNAR2 Stable Knockout HeLa Cell Line
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Stable (KO/Expressing) Cells |
| Tissue Type |
Cervix |
| Organism |
Human (H. sapiens) |
| Donor History | |
| Growth Properties |
Adherent ,epithelial |
| Growth Conditions |
PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. Dulbecco's Modified Eagle Medium (DMEM) ,High Glucose (TM500) + 10% FBS + 1 mM Sodium Pyruvate (TM057) + 1% Penicillin/Streptomycin Solution (G255) ,37.0°C ,5% CO₂. |
| Immortalization Method | |
| Full Information |
https://www.abmgood.com/Human-IFNAR2-Stable-Knockout-HeLa-Cell-Line-T3981.html |
The Human IFNAR2 Stable Knockout HeLa Cell Line (T3981) provides a unique platform for the study of Type I interferon signaling by specifically lacking the IFNAR2 gene. IFNAR2, together with IFNAR1, forms the receptor complex for Type I interferons, initiating a cascade of events leading to immune responses. The absence of IFNAR2 in this cell line eliminates the receptor’s ability to bind interferons, thereby inhibiting subsequent JAK-STAT signaling and gene expression of ISGs. This cell line is particularly valuable for delineating IFNAR2’s specific contributions to the interferon signaling pathway, understanding the redundancy and specificity within the Type I interferon receptor complex, and investigating potential therapeutic avenues in immunology and oncology.Complete list of cell lines from this panel:Cat. T3980 – Human IFNAR1 Stable Knockout HeLa Cell LineCat. T3981 – Human IFNAR2 Stable Knockout HeLa Cell LineCat. T3982 – Human STAT1 Stable Knockout HeLa Cell LineCat. T3983 – Human STAT2 Stable Knockout HeLa Cell Line
Mikrobiologické aplikace
NGS
Rapid testy
PCR plasty
Třepačky
Suché lázně
Fluorometry
Buněčné kultury
PCR, qPCR, RT
Detekce Mycoplasmat
Reverzní transkripce
Alergie
Intolerance
Elisa
Imunologické analyzátory
Veterinární imunologie
Alergie u zvířat
Intolerance u zvířat
Biochemie
Imunoanalýza
