Immortalized Mouse Schwann Cells

Immortalized Mouse Schwann Cells are derived from Twitcher mice. The Schwann cells were immortalized spontaneously in culture, dubbed as the TwS1 cells, and can be used as a murine model for globoid cell leukodystrophy (Krabbe disease) studies. Unlike the normal mouse Schwann cells (Immortalized Mouse Schwann Cells (IMS32), T0295), the TwS1 cells have a nonsense mutation in the GALC genome which is associated with the pathogenesis of Krabbe disease. These cells also exhibit markers for S100, laminin, p75NTR, GFAP and vimentin. Seed cells at high density for optimal growth.