MA-104 Cells

The MA-104 cell line is derived from rhesus monkey kidney epithelial cells and is widely used in virology and vaccine production research. These cells exhibit a typical epithelial morphology, adhering tightly to the substrate and forming a monolayer. Due to their origin, MA-104 cells are particularly permissive to the replication of various viruses, including rotaviruses, polioviruses, and reoviruses, making them an essential tool in virological studies, especially in the propagation and isolation of these pathogens. Their high susceptibility to viral infection allows for efficient viral growth, which is crucial for vaccine development and testing.
In addition to their role in virology, MA-104 cells are also employed in studies focusing on cell biology and physiology, particularly those investigating kidney function and epithelial cell behavior. These cells have been instrumental in understanding the mechanisms of viral entry, replication, and the host-cell response to infection. Researchers also utilize MA-104 cells to study protein expression and post-translational modifications due to their ability to support high levels of protein production.