MADB106 Cells

The MADB106 cell line is a mammary adenocarcinoma cell line derived from the Fischer 344 rat, commonly used in cancer research, particularly in studies investigating metastasis and the immune response to tumors. This cell line is syngeneic to the Fischer 344 rat strain, meaning it is genetically compatible, which allows for the study of tumor growth and metastasis in an immunocompetent environment, closely mimicking physiological conditions. MADB106 cells primarily seed and colonize the lungs when introduced intravenously, making them a valuable model for studying lung metastasis.
Research using MADB106 cells has highlighted the crucial role of natural killer (NK) cells in controlling metastasis. Specifically, NK cells are active during the early stages of metastasis, particularly within the first few hours following tumor cell inoculation. Studies have demonstrated that the depletion of NK cells leads to a significant increase in tumor cell retention and metastasis, underscoring the importance of NK cell activity in resisting tumor spread. Additionally, age-related differences in NK cell activity have been observed, with younger animals showing reduced NK cell-mediated cytotoxicity, resulting in higher susceptibility to metastasis. These findings make MADB106 a pivotal model for exploring the interactions between the immune system and cancer, particularly the mechanisms underlying NK cell-mediated tumor control.