MDA-MB-415 Cells

The MDA-MB-415 cell line is derived from a metastatic site of an adult female patient with breast adenocarcinoma. These cells are epithelial in nature and exhibit characteristics typical of mammary gland epithelial cells. They are known for their utility in studying the molecular and cellular mechanisms underlying breast cancer, including hormone receptor activity and gene expression profiles. The MDA-MB-415 cell line is estrogen receptor-positive (ER+) and HER2 negative, making it particularly valuable for research focused on hormone-responsive breast cancers. Researchers utilize these cells to investigate the role of estrogen signaling in breast cancer progression and to evaluate the efficacy of anti-estrogen therapies.

In terms of growth characteristics, MDA-MB-415 cells grow as adherent monolayers and require a nutrient-rich culture medium to maintain optimal growth and viability. These cells exhibit a moderate doubling time, which makes them suitable for various in vitro assays, including proliferation, apoptosis, and drug sensitivity studies. The genetic profile of MDA-MB-415 cells has been extensively characterized, revealing key mutations and gene expression patterns that are relevant to breast cancer biology. This cell line serves as a critical model for understanding the complex interactions between cancer cells and their microenvironment, aiding in the development of novel therapeutic strategies.