Genetika člověka
Mikrobiologické aplikace
NGS
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Plasty pro buněčnou kultivaci
Systém pro dlouhodobé skladování vzorků
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Biochemie
Imunoanalýza
MuCaP376 Cells
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Tumor Cells |
| Tissue Type |
Prostate |
| Organism |
Mouse (M. musculus) |
| Donor History |
Mouse prostate cancer ,PSA-Cre;PtenLoxP/LoxP genetic engineered mouse model (GEMM) |
| Growth Properties |
Adherent ,epithelial |
| Growth Conditions |
PriCoat™ ECM T25 Flasks (G999) or Applied Cell Extracellular Matrix (G422) are required for cell adhesion to the culture vessels. PriGrow II (TM002) + 10% FBS + 1% Penicillin/Streptomycin Solution (G255) ,37.0°C ,5% CO₂. |
| Immortalization Method |
Tumor Cell Line |
| Full Information |
MuCaP376 is an epithelial prostate cancer cell line from the PSA-Cre targeted Pten KO primary tumors in FVB mice. It forms syngeneic tumors with moderate growth rates in immunocompetent mice, achieving substantial tumor volumes within 1-2 months. These tumors exhibit heterogeneous histologies, including intraductal carcinoma (IDC), adenocarcinoma, and sarcomatoid carcinoma, reflecting the primary Pten KO tumor characteristics. MuCaP376 also shows PI3K pathway activation and is responsive to PI3K inhibitors like GDC0941. This cell line is valuable for studying prostate cancer heterogeneity, tumor aggressiveness, and immune interactions, including moderate levels of CD3+ T-cell infiltration.Additional cell lines from the MuCaP model: Cat. T8301 – MuCaP321 CellsCat. T8303 – MuCaP379AP CellsCat. T8304 – MuCaP379.1 Cells
