SNU-719 Cells

The SNU-719 cell line is a human gastric carcinoma model established from the primary gastric tumor tissue of an adult male patient in Korea. It belongs to a collection of gastric cancer lines developed to support cancer research in East Asia, where gastric cancer prevalence is particularly high. SNU-719 was derived from a moderately differentiated adenocarcinoma and has demonstrated strong attachment to plastic culture surfaces, growing as a diffuse monolayer. The line was maintained in RPMI-1640 medium supplemented with 10% heat-inactivated fetal bovine serum.

Comprehensive biochemical and genetic profiling of SNU-719 revealed expression of carcinoembryonic antigen (CEA) and high levels of tissue polypeptide antigen (TPA) in both supernatant and cell lysate. However, alpha-fetoprotein (aFP) was not detected. Mutation analysis identified alterations in the TP53 gene, although the c-Ki-ras oncogene remained unmutated in this line. These features make SNU-719 a suitable model for studying the molecular mechanisms of gastric adenocarcinoma and for evaluating biomarker expression and therapeutic interventions. Additionally, STR and SNP profiling have confirmed its identity and uniqueness, ensuring the cell line’s reliability for in vitro experimentation.