SW48 Cells

The SW48 cell line is a human colorectal adenocarcinoma cell line derived from an adult patient. This cell line is characterized by its epithelial morphology and adherent growth properties, making it a valuable model for studying colorectal cancer biology and therapeutic responses. SW48 cells exhibit several genetic alterations commonly associated with colorectal cancer, including mutations in the APC, KRAS, and TP53 genes. These genetic features make SW48 cells particularly useful for research focused on the molecular mechanisms of colorectal tumorigenesis and the development of targeted therapies.
In addition to their genetic profile, SW48 cells express carcinoembryonic antigen (CEA), a glycoprotein often used as a tumor marker in colorectal cancer. This expression further enhances the utility of the SW48 cell line in cancer research, allowing for studies on tumor marker expression and its implications in cancer diagnostics and treatment monitoring. The SW48 cell line is also used in drug screening and cancer immunotherapy research, providing a robust in vitro model to evaluate the efficacy and safety of new therapeutic agents. Overall, the SW48 cell line is an essential tool in colorectal cancer research, contributing to our understanding of cancer biology and the development of effective treatments.