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Huntingtin 20Q Stable PC12 Cell Line
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Stable (KO/Expressing) Cells |
| Tissue Type |
Adrenal Gland |
| Organism |
Rat (R. norvegicus) |
| Donor History |
Male ,NEDH rat ,Adrenal gland pheochromocytoma |
| Growth Properties |
Adherent ,small and irregular shaped |
| Growth Conditions |
PriCoat™ T25 Flasks (G299) or Applied Cell Extracellular Matrix (G422) are recommended for optimal cell culture. Dulbecco's Modified Eagle Medium (DMEM) ,High Glucose (TM500) + 5% FBS + 10% Horse Serum + 1% Penicillin/Streptomycin Solution (G255) ,37.0°C ,5% CO₂. |
| Immortalization Method | |
| Full Information |
https://www.abmgood.com/huntingtin-20q-stable-pc12-cell-line.html |
Huntington disease (HD) is an autosomally dominant degenerative disorder resulting from polyglutamine expansion (>37units) in the huntingtin gene. The repeat is often localized in the N-terminal region of huntingtin and the resulting N-terminal fragments accumulate in the nucleus and become toxic to the cells. The HD 20Q Stable PC12 cell line displays the HD 20Q proteins evenly in the cytoplasm.
