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Immortalized Canine Bone Marrow Mesenchymal Stromal Cells (DS1)
| Unit |
1×10⁶ cells / 1.0 ml |
|---|---|
| Cell Type |
Immortalized Cells |
| Tissue Type |
Bone Marrow |
| Organism |
Dog (Canine) |
| Donor History | |
| Growth Properties |
Adherent ,polygonal |
| Growth Conditions | |
| Immortalization Method |
Transduction with retrovirus containing the HPV E6/E7 genes |
| Full Information |
https://www.abmgood.com/immortalized-canine-bone-marrow-mesenchymal-stromal-cells-ds1.html |
Mesenchymal stromal cells are observed to have immunosuppressive effects on lymphocytes. The Immortalized Canine Bone Marrow Mesenchymal Stromal Cells (DS1) cells were generated from mononuclear cells derived from canine bone marrow. The cells were immortalized via transduction of a retrovirus containing the human papilloma virus E6/E7 genes. Phenotypic characterization of the Immortalized Canine Bone Marrow Mesenchymal Stromal Cells (DS1) cells via RT-PCR found that the cell line was weakly positive for CD10, CD29, CD106, moderately positive for CD73 and CD105, and strongly positive for CD90. The Immortalized Canine Bone Marrow Mesenchymal Stromal Cells (DS1) cells are applicable studies to investigate their immunosuppressive effects, especially in inflammatory and immune disease models.
