Immortalized Human Intestinal Microvascular Endothelial Cells – SV40

This immortalized intestinal microvascular endothelial cell line is modified with the Simian Virus 40 (SV40) large T antigen for immortalization. This manipulation allows these cells to bypass the normal cellular senescence and continue proliferating indefinitely, providing a stable and reproducible tool for research. These cells are particularly useful for studying intestinal vascular biology, including barrier functions, angiogenesis, and the interactions between endothelial cells and other cell types within the gut environment. They are also valuable for exploring pathological conditions such as inflammation, cancer metastasis to the gut, and other vascular-related diseases of the intestinal tract. The cell line’s capacity for continuous growth enables extensive experimental manipulation, making it ideal for drug testing and the study of endothelial responses to various stimuli under controlled laboratory conditions.