MDA-MB-453 Cells

The MDA-MB-453 cell line is a widely studied human breast carcinoma cell line derived from the metastatic site of pleural effusion in a female adult patient. This cell line is known for its utility in breast cancer research due to its unique characteristics, including its androgen receptor (AR) positivity and lack of estrogen receptor (ER) and progesterone receptor (PR) expression. These features make MDA-MB-453 an invaluable model for studying triple-negative breast cancer (TNBC) and the role of androgen receptors in breast cancer progression and therapy resistance.

MDA-MB-453 cells exhibit epithelial morphology and adhere to culture surfaces, forming polygonal cell shapes. The cell line is also characterized by its high proliferative capacity and ability to grow in vitro and in vivo, which is essential for preclinical studies involving drug testing and the investigation of molecular pathways. Genetic analysis of MDA-MB-453 cells reveals mutations in key oncogenes and tumor suppressors, including the PIK3CA gene, which is often implicated in cancer cell survival and growth. These cells are also utilized in the study of targeted therapies, particularly those aimed at the PI3K/AKT/mTOR signaling pathway and AR inhibitors, to develop more effective treatments for TNBC patients.